Immune mediated mechanisms of melanocyte destruction
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چکیده
منابع مشابه
Immune mediated mechanisms of melanocyte destruction
Insights into immune reactions against benign and malignant melanocytes may help the development of more efficient immunotherapeutic treatments for melanoma. The interplay between an active systemic antitumor immunity and a responsive local tumor environment is crucial to achieve effective clinical responses. Increasing evidence confirms this strategy can lead to an adequate and durable immunos...
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Mechanism of Immunity The immune system exhibits a range of responses involving humoral factors, immunoglobulin, and sensitized calls of the lymphoid system. The immunoglobulin which posses antibody activity comprise distinct classes of which IgG, IgM, IgA and IgE are the most important, IgG is the predominant class circulating in the blood stream. IgA may be involved in local immune response t...
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In the series celebrating the 50th anniversary of TRANSFUSION (1961-2010), this review will attempt to cover red blood cell (RBC) immunology, that is to say, RBC antigenantibody reactions; it will not cover blood group antigens specifically because they are covered in a separate review by Daniels and Reid. Because the first issue of TRANSFUSION was January/February 1961 and the published materi...
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Much progress has been made in defining the mechanisms by which altered systolic and diastolic function of the heart may be produced by components of the immune system activated during allograft rejection and myocarditis and in patients with dilated cardiomyopathy. It is clear that injury of the vascular bed can occur via both humoral and cellular mediators and probably accounts for the acute a...
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Current strategies for the immunotherapy of melanoma include augmentation of the immune response to tumor antigens represented by melanosomal proteins such as tyrosinase, gp100, and MART-1. The possibility that intentional targeting of tumor antigens representing normal proteins can result in autoimmune toxicity has been postulated but never demonstrated previously in humans. In this study, we ...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2012
ISSN: 2162-402X
DOI: 10.4161/onci.19403